Nanocrystalline silver dressings are increasingly popular for managing the increased bacterial burden in different types of wounds. Evidence for their use is limited, but does suggest favourable results. This article looks at the effect of Acticoat Moisture Control™ in the treatment of various chronic wound types. Twelve patients with a history of recurring infection were assessed using standardised criteria. Marked improvements were seen in 10 of the patients. Four of these case studies are presented, highlighting the effectiveness of the nanocrystalline silver dressing at preventing recurrence of persistent infection.