Surgical site infections (SSIs) pose wound management challenges to both the clinician and patient. An evaluation of three patients following surgical intervention with static wounds was conducted to explore the benefits of adding an antimicrobial primary wound contact layer in conjunction with negative pressure wound therapy (NPWT). All three patients demonstrated positive outcomes regarding atraumatic wound-bed protection, reducing bacterial burden, and “rebooting” of the wound healing process. The author recommends further research on the use of NPWT and antimicrobial primary wound contact layers for the management of SSIs be undertaken.