Acute inflammation is the body’s immediate response to injury. Signals released by damaged tissue increase local fluid, nutrient and immune system cell levels, resulting in swelling, heat, redness and pain. Adequate preparation of the wound bed can help to reduce inflammation and optimise conditions for healing. The TIME framework – which incorporates control of Inflammation and Infection – should be applied as part of a patient-centred treatment pathway (Dowsett and Newton, 2005). Local and systemic factors that contribute to inflammation need to be identified and managed. This Made Easy explains how prolonged inflammation can impact on healing, how to identify inflammation in practice, and which patients are at risk. It also describes how PROMOGRANTM Protease Modulating Matrix and PROMOGRAN PRISMATM Wound Balancing Matrix (KCI, an Acelity company) work to reduce inflammation and support progression to healing.