Wound care is, indisputably, a dynamic field of research and clinical activity. Clinical practice is shaped in part or wholly by guidelines which, in turn, are developed from the repository of available evidence. In the quest for clinical practice established upon the principles of evidence-based medicine, we are led in search of “best available evidence”. We thus need to examine what exactly does ‘best-available evidence’ consist of? For example, one school of thought considers that “A Cochrane Review is a systematic review of research in health care and health policy that is published in the Cochrane Database of Systematic Reviews.” (Cochrane Library, nd)