Skin damage resulting from intrinsic and extrinsic factors has a negative impact on our physical and psychosocial health. Patients at risk of skin breakdown or presenting with damage require a detailed assessment to establish a suitable skin regimen. In many cases, a skin-friendly cleanser, washing with warm water, and the daily application of an emollient is appropriate. This case series evaluates the clinical performance and outcomes of twice-daily octenicare repair creme application on a range of skin conditions. It also reports on the acceptability of octenicare to the clinician and patients.