A new device, charged polystyrene microspheres (CPM), that is applied topically to the wound bed appears to offer hope of wound closure for hard-to-heal wounds, particularly those with exposed bones and tendons. This article presents an evaluation of 54 wounds of different aetiologies that were treated with CPM for an average of 4.5 weeks. 65% achieved significant granulation tissue growth (>75% of the surface of the wound), and 39% achieved complete wound closure, either by natural healing or surgical closure. Charged polystyrene microspheres appear to be a safe and clinically effective treatment option for hard-to-heal wounds.