Hyperbaric oxygen therapy (HBOT) has been used as an adjunct for treating wounds for almost sixty years (Brummelkamp et al, 1961). Wound care provision and treatment options have changed significantly during that time. This choice can be beneficial to clinicians and patients but can lead to a lack of knowledge and understanding of the less common treatment modalities, such as hyperbaric oxygen therapy (Atkin et al, 2019). This article seeks to provide information on the use of hyperbaric oxygen to support healthcare professionals in their decision making. The practicalities of the treatment will be discussed, the mechanisms of action explained and clinical recommendations from Europe and the USA will be presented.