This series of four case studies focuses on patients with difficult-to-debride wounds who were treated with ManukaDress IG (Medicareplus International), which is impregnated with 100% pure, medical-grade manuka honey. ManukaDress IG is indicated for autolytic debridement of necrosis and slough, to encourage granulation and epithelialisation, and can be used on wounds with any level of exudate when used with an appropriate secondary dressing.