Moisture-associated skin damage occurs as a result of prolonged exposure to irritants such as urine, stool, perspiration and exudate. A considerable amount of money is spent on skin protectants in the UK, with a wide range of products available, and clinicians must understand the multiple indications, contraindications and guidelines for product usage. However, gaps in knowledge can lead to misuse, such as unnecessary application of expensive or contraindicated products, adding to ever-increasing budget pressures. This article discusses Total Barrier Protection, a moisture damage treatment strategy that aims to ensure patients consistently receive the right skin care at the right time.