While evidence to date is limited, the economic literature pertaining to negative pressure wound therapy (NPWT) suggests that, when used appropriately, it may have economic benefits compared with conventional wound care. Deciding on the appropriate point to start NPWT and, indeed, when to switch back to advanced wound care, is important and should be primarily based on clinical judgement. However, it may be useful to compare the costs of NPWT with advanced wound care. This article discusses economic considerations for NPWT, and suggests ways in which the weekly cost of treatment can be estimated as an aid to decision-making.