Hydrogel dressings have proven their usefulness in the treatment of chronic wounds. OxyzymeTM , a new novel hydrogel dressing containing an active enzyme system was evaluated in the treatment of patients with chronic venous leg ulcers. The clinical benefits observed included pain management, exudate management and the creation of a healing environment. It is hypothesised that the healing environment is optimised through oxygenation of the wound. The case studies presented here demonstrate the usefulness of this dressing.