In the first and second papers in this series, we introduced research paradigms and the idea of research methodologies and methods. In this, the second of the methodology papers (the last one covered cross-sectional study design), case-control studies will be explored; it should be considered that methodology refers to the overall approach/blueprint that is guiding the design and execution of the study. In future papers in the series, we will examine more research methodologies, as well as some of the terminology associated with undertaking health and social care research.