The increased survival rates of neonates from lower gestations (i.e. 23–4 weeks gestation upwards) have introduced complex issues of skin care and wound management in these vulnerable infants, as skin injuries and wound complications remain a source of potential morbidity. Guiding wound care practice in this area is challenging because of the ethical dilemma of conducting clinical studies within the patient population. This article is aimed at healthcare professionals involved in the care of neonates and provides practical guidance in minimising trauma and pain when managing the wounds of young babies.