Identifying suitable pressure relieving mattresses to meet patient and organisational needs is a challenge for many healthcare professionals. This article describes a small evaluation which explored the use of the Talley Quattro Acute mattress replacement system in an acute NHS trust. Over a seven-month period nine mattresses were evaluated across a range of clinical settings. Sixty-seven patients were assessed and nursed on the mattresses. Despite being a small study the outcomes demonstrated the suitability of the Quattro Acute Mattress for patients at high to very high-risk of pressure ulcer development.