Large wounds on the leg and abdomen can be particularly challenging to manage as dressings are often not big enough to cover the entire wound bed. Patchworked dressings are difficult to apply and there can be slippage, leading to gaps where the wound is exposed or to which retention products can adhere. The successful overlapping of dressings, however, is demanding and expensive. Superabsorbent dressings can be used on large wet wounds, however when saturated they can become heavy, cold and pull at the skin. This small case series examines the use of the new larger-sized Mepitel® One dressings with secondary dressings in the management of eight patients’ wounds.