Epidermal harvesting (EH) is the practice of taking micro-grafts for autologous skin grafting. EH involves applying a device (Cellutome Epidermal Harvesting System, Acelity) with a sterile disposable harvester that heats the donor site skin (typically the medial thigh) to produce epidermal blisters for transplantation as micro-grafts directly onto a recipient site. As an adjunctive therapy, EH is indicated for the treatment of acute and chronic wounds healing by secondary intention. Wound assessment by the interdisciplinary team is key to effective EH practice in plastic surgery outpatients.