Having a mastectomy for breast cancer is stressful in itself without then developing a wound infection and wound breakdown. Particularly, as this may result in a delay in vital chemotherapy treatment, which usually will not commence until the mastectomy wound has healed. This case study of a 53-year-old lady describes the use of portable, single-use Negative Pressure Wound Therapy (NPWT) to aid fast wound healing following mastectomy wound breakdown. The use of this type of portable NPWT enabled the patient to be managed as an outpatient and resulted in a rapid reduction in wound size and exudate level, and promoted healing.