Recent advances in molecular biology, nanotechnology and functional genomics, coupled with an increased understanding of the pathophysiology of chronic wounds have resulted in the development of novel therapies such as tissue engineered substitutes and growth factors. In addition, promising developments in the areas of stem cells and gene therapy have given rise to new hope in modulating non-healing wounds. This article discusses some of the aetiological factors of non-healing wounds, the essential scientific aspects, the current treatment options and the potential future advances in the management of chronic wounds.
