Many factors combine to make hard-to-heal wounds challenging to clinicians. Several different methods have been used to intervene and encourage these wounds to heal, as delay in their healing leaves them open to further complications. Negative pressure wound therapy (NPWT) is an effective treatment to improve the healing rates and closure of many different types of wounds. This article presents data from clinical case reports in which the Mölnlycke Avance® NPWT system was used. The ability of the system to manage exudate, minimise pain at dressing removal and encourage mobility (due to its portability) had a positive effect on patient quality of life.