The Avance® Negative Pressure Wound Therapy (NPWT) system (Mölnlycke Health Care) is easy to use, lightweight, and portable. The system promotes patient mobility and is minimally obtrusive. In this series of case studies, the author looks at the use of the Avance NPWT system, using either a foam or gauze dressing as a therapeutic option, in the treatment of a range of acute and hard-to-heal wounds.