ReferencesAiken KT, Elliott L, Da Costa M (2024) Acute osteomyelitis: How to recognize, diagnose, and treat: A narrative review. JNP 20: 104899
Angel DE, Lloyd P, Carville K, Santamaria N (2011) The clinical efficacy of two semi-quantitative wound-swabbing techniques in identifying the causative organism(s) in infected cutaneous wounds. Int Wound J 8(2): 176-85
Atkin L, Bućko Z, Conde Montero E et al (2019) Implementing TIMERS: The race against hard-to-heal wounds. J Wound Care 28: sup3a
Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R (2020). Type 2 diabetes and its impact on the immune system. Curr Diabetes Rev 16(5): 442-9
Bodavula P, Liang SY, Wu J et al (2015) Pressure ulcer-related pelvic osteomyelitis: a neglected disease? Open Forum Infect Dis 2(3): ofv112
British Medical Journal (2021) BMJ Best Practice: Osteomyelitis. Available at: https://bestpractice.bmj.com/topics/en-gb/354 (accessed 09.10.2025)
Calvo-Wright MDM, Álvaro-Afonso FJ, López-Moral M et al (2023) Is the combination of plain X-ray and probe-to-bone test useful for diagnosing diabetic foot csteomyelitis? A systematic review and meta-analysis. J Clin Med 12(16): 5369
Chadwick P, Ahmad N, Dunn G et al (2022) Local antibiotic delivery: early intervention in infection management strategy. Diab Foot J 25(2): 44-52
Chicco M, Singh P, Beitverda Y et al (2020) Diagnosing pelvic osteomyelitis in patients with pressure ulcers: a systematic review comparing bone histology with alternative diagnostic modalities. J Bone Jt Infection 6(1): 21-32
Cierny G, Mader JT, Penninck JJ (2003) A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res 414: w7-24
Crespo A, Stevens NM, Chiu E et al (2020) Incidence of osteomyelitis in sacral decubitus ulcers and recommendations for management. JBJS Rev
8(6): e0187
Crowther GS, Callaghan N, Bayliss M et al (2021) Efficacy of topical vancomycin- and gentamicin-loaded calcium sulfate beads or systemic antibiotics in eradicating polymicrobial biofilms isolated from diabetic foot infections within an in vitro wound model. Antimicrob Agents Chemother 65(6): e02012-20
Ferguson J, Alexander M, Bruce S et al (2021) A retrospective cohort study comparing clinical outcomes and healthcare resource utilisation in patients undergoing surgery for osteomyelitis in England: a case for reorganising orthopaedic infection services. J Bone Jt Infect 6(5): 151-63
Ferris A (2024) Should bone biopsy be the standard for suspected osteomyelitis in patients with pressure ulcers? J Wound Care 33(3): 202-6
Fletcher J (2023) Interface pressure: what does it mean in clinical practice? Wounds UK 19(3): 52-7
Hofstee MI, Muthukrishnan G, Atkins GJ et al (2020) Current concepts of osteomyelitis: From pathologic mechanisms to advanced research methods. Am J Pathol 190(6): 1151-63
International Working Group on the Diabetic Foot (2023) IWGDF guidelines on the prevention and management of diabetes-related foot disease. Available to download from: https://iwgdfguidelines.org/
International Wound Infection Institute (2022) Wound infection in clinical practice: Principles of best practice. Wounds International.
Available to download from: https://woundsinternational.com/
Jagadeesh N, Abdul A, Shivalingappa VM, Kumar H (2022) Prospective comparative analysis of efficacy of local debridement with or without vancomycin-impregnated calcium sulphate in chronic osteomyelitis. J Orthop 32: 133-8
Kaka AS, Beekmann SE, Gravely A et al (2019) Diagnosis and management of osteomyelitis associated with stage 4 pressure ulcers: Report of a query to the Emerging Infections Network of the Infectious Diseases Society of America. Open Forum Infec Dis 6(11): ofz406
Khansa I, Barker JC, Ghatak PD et al (2018) Use of antibiotic impregnated resorbable beads reduces pressure ulcer recurrence: A retrospective analysis. Wound Repair Regen 26(2): 221-7
Khater AMR, Elkabbani M, El Fahar MH (2022) A retrospective comparative study between muscle flaps and fasciocutaneous flaps in reconstruction of chronic osteomyelitis related wounds of the lower limb in the adult population. J Plast Reconstr Surg 46(1): 37-43
Linsley J, Reel S (2021) The appropriateness of X-ray referrals of osteomyelitis and its timely management with antibiotics: A service evaluation. Diab Foot J 24(3): 1-5
Manas AB, Taori S, Ahluwalia R et al (2021) Admission time deep swab specimens compared with surgical bone sampling in hospitalized individuals with diabetic foot osteomyelitis and soft tissue infection. Int J Low Extrem Wounds 20(4): 300-8
Mikus JR, Worsham J, Aung H et al (2013) The role of bone biopsy in osteomyelitis—utility or futility? JVIR 24(4): s31-2
National Library of Medicine (2023) Osteomyelitis.Available at: https://www.ncbi.nlm.nih.gov/books/NBK532250/ (accessed 23.09.2025)
Norman G, Wong JK, Amin K et al (2022) Reconstructive surgery for treating pressure ulcers. Cochrane Database Syst Rev 10(10): CD012032
Monami M, Bordoni L, Ragghianti B et al (2025) Efficacy and safety of a bio-absorbable antibiotic delivery in calcium sulphate granules for the treatment of osteomyelitis in patients with diabetic foot: A randomized, double blinded, controlled clinical study. The BIG D-FOOT study. Diabetes Obes Metab 27(5): 2552-60
Moore ZEH, van Etten MT, Dumville JC (2016) Bed rest for pressure ulcer healing in wheelchair users. Cochrane Database Sys Rev 2016(10): CD011999
Morley R, Rothwell M, Stephenson J et al (2022) Complex foot infection treated with surgical debridement and antibiotic loaded calcium sulfate: a retrospective cohort study of 137 cases. J Foot Ankle Surg 61(2): 239-47
National Health Service (2023) Osteomyelitis. Available at: https://www.nhs.uk/conditions/osteomyelitis/ (accessed 21.05.2025)
National Health Service England (2022) Patient Safety Incident Response Framework. Available at: https://www.england.nhs.uk/patient-safety/patient-safety-insight/incident-response-framework/ (accessed 09.10.2025)
National Institute for Health and Care Excellence (2024a) Pressure ulcers: How should I diagnose and assess a person with a pressure ulcer? Available at: https://cks.nice.org.uk/topics/pressure-ulcers/diagnosis/diagnosis-assessment/#:~:text=Pressure%20ulcers%20should%20be%20diagnosed,ulcers%20into%206%20categories/stages (accessed 24.05.2025)
National Institute for Health and Care Excellence (2024b) How should I prevent pressure ulcers in adults? Available at: https://cks.nice.org.uk/topics/pressure-ulcers/management/prevention-of-pressure-ulcers/ (accessed 21.08.2025)
National Wound Care Strategy Programme (2023) Pressure ulcer recommendations and
clinical pathway
Oozageer Gunowa N, Hutchinson M, Brooke J, Jackson D (2018) Pressure injuries in people with darker skin tones: A literature review. J Clin Nurs 27(17-18): 3266-75
Reyes MC, Suludere MA, Tarricone AN et al (2024) Residual diabetic foot osteomyelitis after surgery leads to poor clinical outcomes: A systematic review and meta-analysis. Wound Rep Reg 32: 872-9
Wong D, Holtom P, Spellberg B (2018) Osteomyelitis complicating sacral pressure ulcers: Whether or not to treat with antibiotic therapy. Clin Infect Dis 68(2): 338-42
World Union of Wound Healing Societies (2020) Optimising wound care through patient engagement. Wounds International. Available to download from: www.woundsinternational.com
Wounds UK (2018) Best Practice Statement: Improving holistic assessment of chronic wounds. Wounds UK, London. Available to download from: www.wounds-uk.com
Wounds UK (2021) Best Practice Statement: Addressing skin tone bias in wound care: assessing signs and symptoms in people with dark skin tones. Wounds UK, London. Available to download from: www.wounds-uk.com