The diagnosis and management of wound infection continue to be highly challenging aspects of wound care. In recent years, the role of topical antimicrobial dressings to treat wound infection has gained recognition. However, questions have been raised about the efficacy and apparent expense of silver dressings. This four-week prospective, non-comparative evaluation examined the impact of the silver-containing dressing SILVERCEL® Non-Adherent (Systagenix) on signs and symptoms of infection in wounds of various aetiologies. The evaluation found that when used appropriately SILVERCEL Non-Adherent treated infection effectively and was associated with improvements in malodour, purulent exudate, exudate level, periwound erythema, bleeding at dressing change and pain.