This article outlines the key actions of honey when used as a treatment for wounds and examines the evidence base for its efficacy and impact on clinical outcomes. It also provides a guide to the assessment of wounds in order to identify infection, to ensure that antimicrobial dressings such as honey are used appropriately. Finally, the Mesitran range of dressings (Aspen, Redditch) is described and individual case reports presented which demonstrate the use of these products in clinical practice.