This article will explore the literature to identify why people with diabetes are at a high risk of lowerlimb amputation. The significance of the problem, aetiology, evidence-based prevention and screening measures, as well as infection prevention will also be discussed. Many diabetes-related lower-limb amputations can be avoided or delayed by early detection of the problem. It is also important to maintain good glycaemic control, and encourage multidisciplinary involvement to ensure that the person takes responsibility for their own health and well-being.