Background: Hyperbaric oxygen therapy (HBO) may be a useful adjunct for chronic non-healing wounds when the aetiology includes a hypoxic component. Occasionally, HBO is administered for unusual cases that have no obvious hypoxic involvement. Aims: To assess whether HBO would be beneficial for chronic non-healing wounds with no obvious hypoxic component. Methods: Three cases of chronic wounds with no apparent hypoxic complications treated with HBO were reviewed. Results: All three patient cases reviewed demonstrated improved wound healing during their course of HBO. Conclusion: These cases suggest HBO can be beneficial for chronic non-healing wounds with no obvious hypoxic component.