Medical device-related pressure ulcers (MDRPUs) can be a key indicator of patient safety and nursing quality in healthcare settings (Jackson et al, 2019). Preventing the development of this type of pressure ulcer can be challenging since the medical device may be an essential part of the patient’s care and treatment plan (Black and Kalowes, 2016). The use of silicone between the skin and the device has been recommended as one method of reducing the risk of developing MDRPUs (Galetto et al, 2019). Aim: To assess how well Dermisplus Prevent maintains skin integrity compared to the current product used. Method: Twenty evaluation forms for Dermisplus Prevent were completed to assess its performance against specific criteria. Results: The product was well reviewed when assessing pressure redistribution, ease of use and patient comfort. All staff reported that the product performed better than or the same as the current product used in practice. Conclusion: Dermisplus Prevent appears to be an effective and cost-effective product to assist in the prevention of pressure ulcers, including MDRPUs.