Marjolin’s ulcers are rare and aggressive malignant transformations seen in scar tissue and chronic wounds. The majority of the malignant transformations are due to squamous cell carcinoma. Here, Trudie Young gives an overview of the condition — its incidence, pathophysiology, clinical presentation and diagnosis as well as therapeutic management options and treatment plans required to ensure optimal care and good quality of life for patients with Marjolin’s ulceration.