Polyhexamethylene biguanide (PHMB) is a synthetic compound with a broad-spectrum antimicrobial action. PHMB works by disrupting microbial cell membranes and metabolism, interfering with function and, ultimately, destroying the microbial cell. Due to its mechanism of action, development of resistance is unlikely. PHMB has been used in wound care products for some time and has demonstrated reductions in wound pain, odour and slough. This Made Easy looks at the role of PHMB as a topical antiseptic and focuses on a new absorbent dressing, CelluDress-PHMB, for the management of infected wounds or those at risk of infection.